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This diagnostic assessment subjected a penicillin allergy decision rule (PEN-FAST), derived from a prospective cohort of patients tested for penicillin allergy to internal and external validation among 622 patients and 945 patients, respectively. The tool was found to be practical and had a high negative predictive value of 96.3% of ruling-out patients with severe penicillin allergy.
The PEN-FAST tool uses a patient’s history of penicillin allergy to identify low-risk penicillin allergies that can be detected without formal allergy testing. Specifically, a PEN-FAST score of <3 can be used to detect patients who have a low risk of penicillin allergies, and rule-out those with a severe allergy. This tool may aid the risk stratification of patients with penicillin allergy and help formulate treatment plans.
